Page 19 - Demo

%uc815%ud615%uc678%uacfc%ud559%ud68c%uc18c%uc2dd19%ubb38%ud5cc 1). %uadf8%ub7ec%ubbc0%ub85c %uc2e0%uccad%uc778%uc5d0%uac8c %uace8%ubc00%ub3c4%uac80%uc0ac %ud6c4 %uace8%ub2e4%uacf5%uc99d %uc57d%uc81c%uc778 %ud504%ub864%ub9ac%uc544%ub97c %ud22c%uc5ec%ud55c %uac83%uc740 %uc57d%ubb3c %uc0ac%uc6a9%uc758 %uc801%uc751%uc99d%uacfc %uc801%uc808%uc131 %uce21%uba74%uc5d0%uc11c %ud569%ub2f9%ud55c %uc870%uce58%ub85c %uc0dd%uac01%ud560 %uc218 %uc788%uc74c.%ud504%ub864%ub9ac%uc544 %ud22c%uc57d %ud6c4 %uacbd%uacfc%uad00%ucc30%uc758 %uc801%uc808%uc131%uc2e0%uccad%uc778%uc740 1%uc6d4 2%uc77c %ud504%ub864%ub9ac%uc544 60 mg%uc744 %ud55c %ucc28%ub840 %ud22c%uc5ec%ubc1b%uc740 %ud6c4 %uc804%uc2e0%uc1e0%uc57d %ubc0f %uad6c%ud1a0 %uc99d%uc0c1%uc774 %ub098%ud0c0%ub098%uc11c %ub2e4%uc74c %ub0a0%uc778 1%uc6d4 3%uc77c %ud53c%uc2e0%uccad%uc778 %ubcd1%uc6d0%uc5d0 %ub0b4%uc6d0%ud568. %ud53c%uc2e0%uccad%uc778%uc740 %ud504%ub864%ub9ac%uc544%uc5d0 %uc758%ud55c %uacfc%ubbfc%ubc18%uc751%uc73c%ub85c %ud310%ub2e8%ud558%uace0 %ub300%uc99d%uc801 %uce58%ub8cc%ub97c %uc2dc%ud589%ud558%uc600%uace0, 1%uc6d4 19%uc77c %ub0b4%uc6d0 %uc2dc %uc784%ud50c%ub780%ud2b8 %uc218%uc220%uc744 %ubc1b%uc744 %uc608%uc815%uc774%ub77c%ub294 %uc2e0%uccad%uc778 %uc774%uc57c%uae30%uc5d0 %ud504%ub864%ub9ac%uc544 %uc8fc%uc0ac %ud22c%uc5ec%ub97c %ubc1b%uc740 %uc9c0 6%uac1c%uc6d4 %ud6c4%uc5d0 %uc784%ud50c%ub780%ud2b8 %uc218%uc220%uc774 %uac00%ub2a5%ud558%ub2e4%uace0 %uc124%uba85%uc744 %ud558%uc600%uc74c. %ud504%ub864%ub9ac%uc544 %ud22c%uc5ec %ud6c4 %uc57d%ubb3c %ubd80%uc791%uc6a9%uc5d0 %ub300%ud55c %ucc98%uce58%uc640 %uc784%ud50c%ub780%ud2b8 %uc2dc%uc220%uc774 %uac00%ub2a5%ud55c %uc2dc%uc810%uc5d0 %ub300%ud558%uc5ec %uc801%uc808%ud788 %uc124%uba85%ud558%uc600%uc73c%ubbc0%ub85c, %uacbd%uacfc%uad00%ucc30%uc5d0%uc11c %ubd80%uc801%uc808%ud55c %ubd80%ubd84%uc740 %uc5c6%ub294 %uac83%uc73c%ub85c %uc0ac%ub8cc%ub428.%ub098. %uc778%uacfc%uad00%uacc4%ud504%ub864%ub9ac%uc544 %ud22c%uc57d %ud6c4 %uad6c%ud1a0, %uc804%uc2e0 %uc1e0%uc57d %uc99d%uc0c1%uc758 %uc6d0%uc778(%ud53c%uc2e0%uccad%uc778 %ubcd1%uc6d0%uc5d0%uc11c%uc758 %ud22c%uc57d %ubc0f %ud22c%uc57d %ud6c4 %ucc98%uce58 %uc0c1 %uacfc%uc2e4 %uc5ec%ubd80%uc640%uc758 %uad00%ub828 %uc5ec%ubd80 %ud3ec%ud568)%ud504%ub864%ub9ac%uc544 %ud22c%uc57d %uc774%ud6c4 %ubc1c%uc0dd%ud560 %uc218 %uc788%ub294 %uc804%uc2e0%uc801%uc778 %uc704%uc57d%uac10 %ub4f1%uc758 %ubd80%uc791%uc6a9%uc744 %uacbd%ud5d8%ud55c %uac83%uc73c%ub85c %ubcf4%uc784. %uc774%ub7f0 %uacbd%uc6b0%uc5d0%ub294 %ub300%ubd80%ubd84 %uc9c4%ud1b5%uc18c%uc5fc%uc81c %ub4f1%uc758 %ucc98%ubc29%uc73c%ub85c %uc99d%uc0c1%uc758 %ud638%uc804%uc744 %uae30%ub300%ud560 %uc218 %uc788%uc73c%uba70, %uc2ec%ud55c %uc99d%uc138%ub97c %ubcf4%uc774%ub294 %uacbd%uc6b0%uc5d0%ub294 %ud504%ub864%ub9ac%uc544 %uc7ac%ud22c%uc5ec%ub294 %uc5b4%ub824%uc6b8 %uc218 %uc788%uc74c. %uadf8%ub7ec%ubbc0%ub85c %ud22c%uc57d %ud6c4 %ubc1c%uc0dd%ud55c %uc774%uc0c1 %uc99d%uc0c1%uc740 %ud53c%uc2e0%uccad%uc778 %ubcd1%uc6d0%uc758 %ucc98%uce58 %uc0c1 %uacfc%uc2e4%uc740 %uc544%ub2c8%uace0, %uc57d%ubb3c%uc758 %ubd80%uc791%uc6a9%uc73c%ub85c %uc0dd%uac01%ud560 %uc218 %uc788%uc74c(%ucc38%uace0%ubb38%ud5cc 1).%uc2e0%uccad%uc778%uc758 %ud604 %uce58%uc544 %uc0c1%ud0dc%uc758 %uc6d0%uc778(%ud53c%uc2e0%uccad%uc778%ubcd1%uc6d0%uc5d0%uc11c%uc758 %ud22c%uc57d %ubc0f %ud22c%uc57d %ud6c4 %ucc98%uce58 %uc0c1 %uacfc%uc2e4%uc5ec%ubd80%uc640%uc758 %uad00%ub828%uc5ec%ubd80 %ud3ec%ud568)%uc57d%ubb3c %uad00%ub828 %ud131%ubf08 %ubb34%ud608%uc131%uad34%uc0ac(medication related osteonecrosis of ja MRONJ)%uc758 %uc815%uc758%ub294 1) %uace8%ud761%uc218 %uc5b5%uc81c%uc81c %uc7a5%uae30 %uc0ac%uc6a9, 2) %ud131%ubf08 %ub178%ucd9c %ub610%ub294 8%uc8fc %uc774%uc0c1%uc758 %ub204%uacf5, 3) %ubc29%uc0ac%uc120 %uce58%ub8cc%uc758 %uacfc%uac70%ub825%uc774 %uc5c6%ub294 %uacbd%uc6b0%ub85c %uc54c%ub824%uc838 %uc788%uc74c(%ucc38%uace0%ubb38%ud5cc 1). %uc2e0%uccad%uc778%uc758 %uc2e0%uccad%uc678 %u25c7%u25c7%u25c7%u25c7%u25c7%uce58%uacfc%ubcd1%uc6d0 %uae30%ub85d%uc5d0 %uc758%ud558%uba74 %u2018%uace8%uc218%uc5fc%uc744 %ubc30%uc81c%ud55c %ub9cc%uc131%uce58%uc8fc%uc5fc%uc758 %uc9c4%ub2e8%u2019%uc744 %ud655%uc778%ud560 %uc218 %uc788%uc74c. %uc989, %ud504%ub864%ub9ac%uc544 %ud22c%uc57d %ud6c4 %ubc1c%uc0dd%ud560 %uc218 %uc788%ub294 %uc57d%ubb3c %uad00%ub828 %ud131 %ubf08 %ubb34%ud608%uc131%uad34%uc0ac(MRONJ)%uc758 %uc18c%uacac%uc774 %uc544%ub2cc %ub9cc%uc131%uce58%uc8fc%uc5fc%uc758 %uc9c4%ub2e8%uc774%ubbc0%ub85c %u2018%ud504%ub864%ub9ac%uc544 %uc8fc%uc0ac%ub85c %uc778%ud574 %uc787%ubab8%uc774 %uad34%uc0ac%ub418%uc5c8%ub2e4%u2019%ub294 %uc2e0%uccad%uc778%uc758 %uc8fc%uc7a5%uc740 %ubc1b%uc544%ub4e4%uc774%uae30 %uc5b4%ub824%uc6c0. %ub300%ud55c%uace8%ub300%uc0ac%ud559%ud68c %ub4f1%uc740 %ud504%ub864%ub9ac%uc544%uc640 %uac19%uc740 %uace8%ud761%uc218 %uc5b5%uc81c%uc81c%ub97c %ubcf5%uc6a9%ud558%uac70%ub098 %uc8fc%uc0ac %uce58%ub8cc %uc911%uc778 %uace8%ub2e4%uacf5%uc99d %ud658%uc790%uc758 %uce58%uacfc %uc218%uc220 %uc2dc %u2018%uc57d%ubb3c %uad00%ub828 %ud131 %uace8%uad34%uc0ac%uc99d%u2019%uc758 %ube44%uc728%uc774 %ube44%ub85d %ub0ae%uc740 %ud3b8%uc774%uc9c0%ub9cc, %ud658%uc790%uc5d0%uac8c %uadf8 %ubc1c%uc0dd %uac00%ub2a5%uc131%uc744 %uc54c%ub9ac%uace0, %ud574%ub2f9 %uc57d%uc81c%uc758 %uc911%ub2e8(drug-holiday) %ud544%uc694%uc131 %ubc0f %uadf8 %uae30%uac04%uc5d0 %ub300%ud574 %uc758%uacfc%uc801 %uc790%ubb38%uc744 %uad6c%ud560 %ud544%uc694%uac00 %uc788%ub2e4%uace0 %uad8c%uace0%ud568. %ud558%uc9c0%ub9cc %uc774%ub294 %uc7a5%uae30%uac04(3%ub144 %uc774%uc0c1) %ud22c%uc5ec%uac00 %uc788%uc5c8%ub358 %uacbd%uc6b0%uc774%uc9c0, 1%ud68c %ud22c%uc5ec%uac00 %uc788%uc5c8%ub358 %uacbd%uc6b0%ub294 %uc544%ub2d8. %uc774%uc5d0 %uad00%ud558%uc5ec %ubcf8 %uac74%uc5d0%uc11c %ud3d0%uacbd %ud6c4 %uace8%ub2e4%uacf5%uc99d%uc73c%ub85c %uc9c4%ub2e8%ub41c %uc2e0%uccad%uc778%uc5d0%uac8c %ud504%ub864%ub9ac%uc544 %ud22c%uc57d %uc804 %uc57d%uc81c %uad00%ub828 %ubd80%uc791%uc6a9%uc744 %uc124%uba85%ud588%ub294%uc9c0 %uae30%ub85d%uc0c1 %ud655%uc2e4%uce58 %uc54a%uc740 %uc810%uc774 %uc788%uc74c. %ub9cc%uc77c %uc774%ub7ec%ud55c %ubd80%uc791%uc6a9 %uc5ec%ubd80%ub97c %ubbf8%ub9ac %uc124%uba85%ud558%uc9c0 %uc54a%uc558%ub2e4%uba74, %uc2e0%uccad%uc778%uc774 %uc784%ud50c%ub780%ud2b8 %uc2dc%uc220%uc774 %ud544%uc694%ud55c %uc0c1%ud669%uc5d0%uc11c 1%uc6d4 2%uc77c %ud55c %ucc28%ub840 %ud504%ub864%ub9ac%uc544 %ud22c%uc5ec%ub85c %uc778%ud574 %uc2dc%uc220%uc774 6%uac1c%uc6d4 %uc815%ub3c4 %ub2a6%uc5b4%uc9c4 %uc0c1%ud669%uc774 %uc124%uba85%uc758%ubb34%uc5d0 %ub530%ub978 %uc790%uae30 %uacb0%uc815%uad8c%uc744 %uce68%ud574%ud558%uc5ec %uc77c%ubd80 %uc544%uc26c%uc6b4 %uc810%uc774 %uc788%ub2e4%ub294 %uc758%uacac%uc774 %uc788%uc5c8%uc74c.%ub2e4. %uc885%ud569%uc18c%uacac%ubcf8 %uac74%uc5d0 %ub300%ud55c %uc2e0%uccad%uc778%uc758 %uc8fc%uc7a5%uc740 %ub2e4%uc74c%uacfc %uac19%uc74c. (1) %ud504%ub864%ub9ac%uc544 %ud22c%uc5ec %ud6c4 %uc804%uc2e0 %uc1e0%uc57d%uacfc %uad6c%ud1a0 %uac19%uc740 %uc99d%uc0c1%uc774 %ubc1c%ud604%ud568. (2) %ud504%ub864%ub9ac%uc544 %ud22c%uc5ec %ud6c4 %uc57d%ubb3c %uad00%ub828 %ud131%ubf08 %ubb34%ud608%uc131 %uad34%uc0ac (medication related osteonecrosis of ja MRONJ) %uac00 %ubc1c%uc0dd%ud568. %uc774%uc5d0 %uad00%ud55c %uac10%uc815%ubd80 %ud68c%uc758 %uacb0%uacfc%ub294 %ub2e4%uc74c%uacfc %uac19%uc74c. (1) %ud504%ub864%ub9ac%uc544 %ud22c%uc5ec %ud6c4 %ubc1c%uc0dd%ud55c %uc804%uc2e0 %uc99d%uc0c1%uc740 %uc57d%uc81c %ubd80%uc791%uc6a9%uc774%uba70 %uc774%uc5d0 %ub300%ud55c %ud53c%uc2e0%uccad%uc778 %ubcd1%uc6d0%uc758 %ucc98%uce58%ub294 %uc801%uc808%ud558%uc600%uc74c. (2) %uc2e0%uccad%uc778%uc758 %uad6c%uac15 %uc9c8%ud658%uc740 %uc57d%ubb3c %uad00%ub828 %ud131%ubf08 %ubb34%ud608%uc131%uad34%uc0ac (medication related osteonecrosis of ja MRONJ)%uc774 %uc544%ub2c8%uace0 %uce58%uc8fc%uc5fc%uc774%uba70, %uc774%ub294 %ud55c %ucc28%ub840 %ud504%ub864%ub9ac%uc544 %ud22c%uc5ec%uc5d0 %uc758%ud558%uc5ec %ubc1c%uc0dd%ud55c %uc9c8%ud658%uc774 %uc544%ub2d8.[ %uc870%uc815 %uacb0%uacfc ]%ubcf8 %uac74%uc740 %uc870%uc815 %ud569%uc758%ud558%uc600%uc74c.[ %ucc38%uace0 %ubb38%ud5cc ]1. %ub300%ud55c%uc815%ud615%uc678%uacfc%ud559%ud68c, %ucd5c%uc2e0%uc758%ud559%uc0ac, %uc815%ud615%uc678%uacfc%ud559 8%ud310, 2020, p: 345- 364[ %uc608%ubc29 Tip ]%ud504%ub864%ub9ac%uc544(Prolia)%ub294 RANK ligand%ub85c%uc11c %uace8%ud761%uc218 %uc5b5%uc81c %uc791%uc6a9%uc744 %ud558%uba70 %ube44%uc2a4%ud3ec%uc2a4%ud3ec%ub124%uc774%ud2b8%uc758 %uc0ac%uc6a9 %uae08%uae30%ub098 %uce58%ub8cc %ud6a8%uacfc%uac00 %uc5c6%ub294 %uacbd%uc6b0 %uc801%uc751%uc99d%uc774%ub098 %uc774%uc0c1 %ubc18%uc751%uc73c%ub85c %ud131%ubf08%uad34%uc0ac, %ube44%uc804%ud615 %ub300%ud1f4%uace8 %uace8%uc808, %uc800%uce7c%uc298%ud608%uc99d %ub4f1%uc774 %uc788%ub2e4%uace0 %uc54c%ub824%uc838 %uc788%uc74c. %ubcf8 %uac74%uc758 %uacbd%uc6b0 %ud504%ub864%ub9ac%uc544 1%ud68c %ud22c%uc5ec%ub85c %ud131%ubf08 %uad34%uc0ac%uac00 %ubc1c%uc0dd%ud55c %uac83%uc740 %uc544%ub2c8%ub098 %uc774%ub85c %uc778%ud558%uc5ec %uc784%ud50c%ub780%ud2b8 %uc2dc%uc220%uc774 %ud544%uc694%ud55c %uc0c1%ud669%uc5d0%uc11c %uc2dc%uc220%uc774 6%uac1c%uc6d4 %uc815%ub3c4 %ub2a6%uc5b4%uc9c4 %uc0c1%ud669%uc774 %ubc1c%uc0dd%ud558%uc600%uc73c%ubbc0%ub85c %uc57d%ubb3c %uad00%ub828 %ud131%ubf08 %ubb34%ud608%uc131%uad34%uc0ac(MRONJ)%ub97c %ucd08%ub798%ud560 %uc218 %uc788%ub294 %uc57d%uc81c%uc778 %ube44%uc2a4%ud3ec%uc2a4%ud3ec%ub124%uc774%ud2b8%ub098 %ud504%ub864%ub9ac%uc544 %uc8fc%uc0ac%uc81c %uc0ac%uc6a9 %uc2dc %uc784%ud50c%ub780%ud2b8 %uc2dc%uc220 %uacc4%ud68d %uc5ec%ubd80%uc640 %uc57d%uc81c%uc758 %ubd80%uc791%uc6a9%uc5d0 %ub300%ud55c %uc124%uba85%uc744 %uc790%uc138%ud788 %ud558%ub294 %uac83%uc774 %ubc14%ub78c%uc9c1%ud558%ub2e4%uace0 %uc0ac%ub8cc%ub428.